Publications

Wai T, Saita SNolte HMüller SKönig TRichter‐Dennerlein RSprenger H-GMadrenas JMühlmeister M, Brandt UKrüger MLanger T.  The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i‐AAA protease YME1L.  EMBO reports (2016) e201642698

Hartmann B, Wai T*, Hu H, Fischer-Zirnsak B,  Stenzel W, Graef R,  van den Heuvel L, Ropers H-H,  Wienker TF, Hübner C, Langer T, Kaindl AM.  Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.  eLife 2016;10.7554/eLife.16078.

Wai T and Langer T.  Mitochondrial dynamics and metabolic regulation.  Trends Endocrinol Metab.  2016 Jan 2. pii: S1043-2760(15)00236-2  

Wai T*, Garcia-Prieto, J*, Baker MJ, Merkwirth C, Bénit P, Rustin P, Ruperez FJ, Barbas C, Ibañez B, Langer T.  Imbalanced OPA1 processing and mitochondrial fragmentation causes heart failure in mice.  Science 4 December 2015: 350 (6265)

Lagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG. SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation. PLoS Genet. 2015 Aug 6;11(8):e1005423. 

Mitsopoulos P, Chang YH, Wai T, König T, Dunn SD, Langer T, Madrenas J. Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mol Cell Biol. 2015 May;35(10):1838-47

Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC. The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Cell Rep. 2015 Feb 12. pii: S2211-1247(15)00032-7.

Anand R*, Wai T*, Baker MJ, Kladt, N, Schauss AC, Rugarli E, Langer T.  The i-AAA protease and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.  J Cell Biol. 2014 Mar 17; 204(6); 919-29  * equal contribution

 Potting C, Tatsuta T, Koenig T, Altonen M, Wai T, Langer T TRIAP1/PRELI complexes prevent apoptosis mediating intramitochondrial transport of phosphatidic acid.  Cell Metab 2013

Jokinen R, Marttinen P, Sandell HK, Manninen T, Teerenhovi H, Wai T, Teoli D, Loredo-Osti JC, Shoubridge EA, Battersby BJ. Gimap3 regulates tissue-specific mitochondrial DNA segregation. PLoS Genet. 2010 Oct 14;6(10):

Sasarman F, Brunel-Guitton C, Antonicka H, Wai T, Shoubridge EA; LSFC Consortium. LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria. Mol Biol Cell. 2010 Apr 15;21(8):1315-23.

Wai T, Ao A, Zhang X, Cyr D, Dufort D, Shoubridge EA. The role of mitochondrial DNA copy number in mammalian fertility. Biol Reprod. 2010 Jul;83(1):52-62.

Wai T, Teoli D, Shoubridge EA.  The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes during oocyte maturation in early postnatal life. Nature Genetics. 2008. Dec;40(12):1484-8.

Shoubridge EA, Wai T. Sidestepping mutational meltdown. Science. 2008 Feb 15;319(5865):914-5.

Shoubridge EA, Wai T. Mitochondrial DNA and the mammalian oocyte. Curr Top Dev Biol. 2007;77:87-111.